Benign Cystic Mesothelioma Of The Peritoneum

Symptoms aren't specific, and the differential analysis is vast, together with cystic lymphangioma, mucinous cystadenoma, cystic teratoma and pseudomyxoma retroperitonei. There are not any evidence-based remedy methods for BCM, and even if it is thought of as a benign tumor, this tumor has a high local recurrence rate. Imaging with ultrasound and CT may be helpful tools in figuring out cystic formations but won't differentiate BMPM from other comparable disease processes. CT scans can provide particulars in regards to the location and extent of the disease. Lesions will normally show thin-walled, multiloculated, multicystic lots. Benign multicystic peritoneal mesothelioma is a uncommon, benign cystic tumor arising from the peritoneum.

Some MCPM had been additionally found positive for the estrogen and progesterone receptors. Lymphangioma has crucial differential imaging prognosis, nevertheless it occurs primarily in the pediatric inhabitants and don't mesothelioma claims center have a gender or regional predilection . Linda Molinari has greater than 15 years of experience as a author and advocate for mesothelioma patients and a ban on asbestos. This website is meant for pathologists and laboratory personnel but not for sufferers.

When a affected person has belly signs, and a bodily exam reveals a palpable mass, the subsequent step is a CT scan, ultrasound, or MRI to picture the belly cavity. Until now, there have been only a few instances where benign cystic mesothelioma turned malignant. These cases embrace a six-month-old baby and a thirty-six-year-old female. 10] imagine that BMPM might be the outcome of a peritoneal reactive proliferation, forming multiple peritoneal inclusion cysts, and never a true neoplasm. The natural historical past of this disorder, with its nice tendency to local recurrence and its tumor-like appearance, suggests its neoplastic pathogenesis, but both of the speculation can be argued.

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The lesion had increased in size and was approximately 9.8 cm in the biggest dimension. The colonoscopic evaluation did not demonstrate any massive bowel involvement. Subsequent CT-guided core needle biopsy revealed proteinaceous fluid with few inflammatory cells.

Some research suggest cystic mesothelioma develops in response to foreign fibers and dusts. Another possible trigger is continual irritation similar to a prior surgical procedure or endometriosis. Other studies counsel that feminine intercourse hormones can set off its growth.

There are a few methods to differentiate between growths that look similar. Doctors can use a CT scan, ultrasound or MRI to visualize tumors, but these exams can’t confirm a diagnosis. The finest method to diagnose cystic mesothelioma is by performing a biopsy with a method known as laparoscopy, a minor surgical procedure that makes use of a skinny tube fitted with a lightweight and camera. This type of most cancers is characterized by clean, thin-walled cysts held together by a fragile fibrovascular tissue.

She had no functional complaints and stored a slight stomach distension. May 5, 2020 A 22-year-old male with no previous history of heart problems offered after a high-speed rollover motorized vehicle collision. All authors contributed to the design and interpretation of the research and to further drafts. Written knowledgeable consent was obtained from the affected person for publication of this case report and any accompanying images.

In immunohistochemical analysis, constructive expression of calretinin by the mesothelial cells is always seen . A benign cystic mesothelioma is an inclusion cyst found within the peritoneal cavity and has no specific medical presentation. Benign cystic mesotheliomas have a excessive recurrence price and should undergo malignant transformation. Final pathology revealed benign multicystic mesothelioma with calretinin-positive immunohistochemical staining .

To ensure a high quality of life and early detection of recurrent, malignant tumors, sufferers should have frequent monitoring and follow up appointments after completing benign mesothelioma therapy. Well-differentiated papillary mesothelioma has fewer reported case research, so information for survival charges and fee of recurrence is proscribed. However, one study found a 10-year survival rate of 30.8% for sufferers with WDPM. Because the tumor is so distinct from different mesothelioma tumors, diagnosing this cancer is normally straightforward.

The mesothelial origin was later confirmed by electron microscopy . A few stories proposed a possible genetic or familial predisposition for BMPM. Specifically, one case report, revealed by Curgunlu et al. , describes a person with familial Mediterranean fever who developed BMPM. Although familial Mediterranean fever is linked to development of malignant mesothelioma, the patient was discovered to have BMPM without malignant mesothelioma.

The resected tumor was forty five mm in length and had traits just like the previously resected tumor. The presence of calretinin and D2-40 on immunohistochemistry led to the prognosis of BMPM. There was no recurrence of BMPM for 33 months after the secondary surgery. Benign multicystic peritoneal mesothelioma is a very uncommon benign cystic tumor arising from the peritoneal mesothelium .

However, hemorrhagic cysts might seem as hyperintense lesions on T1 and hypointense on T2. The imply diameter of MPCM is 13 cm on the time of analysis . CT scan is used to gauge the location and the extent of the cystic mass, the place lesion appears as a low-density, multi-loculated, and thin-walled multicystic mass . However, the outcomes obtained by US and CT-scans do not differentiate MCPM from different cystic mass. An adenomatoid mesothelioma tumor is slow-growing and non-cancerous, affecting each men and women.

Despite conservative administration, she developed recurrent umbilical hernia, tense ascites, and umbilical fistula . During the sixth laparoscopic exploration, she was found to have malignant mesothelioma arising from a benign cystic lesion. The inguinal, internal, and external iliac, para-aortic, and inferior deep epigastric and celiac lymph nodes have been found to be concerned.

Gross examination of the eliminated specimen discovered a thin-walled cystic mass with multiple hooked up daughter cysts. The first patient was a 68-year-old Caucasian male who underwent routine ventral and inguinal hernia repair; however in the course of the process he was by the way came upon to have BMPM. Patient historical past was important for hypertension, lengthy duration of smoking, and exposure to asbestos whereas working within the automotive trade. He underwent a CT scan of the chest, abdomen, and pelvis, which revealed a large cystic mass filling the right hemiabdomen and the pelvis; however no abnormality was seen in chest. The patient underwent cytoreductive surgical procedure and HIPEC without any main postoperative complications. Patient medical history was significant for early stage prostate most cancers treated with prostatectomy.

Well-differentiated papillary mesothelioma is an uncommon, non-cancerous tumor typically found in girls. Most instances are asymptomatic, though ache and swelling have been reported. This kind of mesothelioma is most common in the peritoneum, with uncommon situations within the pericardium, pleura and tunica vaginalis.

However, we can not answer medical or research questions or give advice. Immunohistochemical staining can extra accurately establish cells of a benign tumor by particularly targeting them with antibodies. In the few men identified, the tumor most often originated in the peritoneum across the rectum and bladder. This web page has been reality checked by a PhD who focuses on cancer research. Sources of knowledge are listed on the backside of the article.

Anything above 5 should be considered above common.While all registered Cureus customers can price any printed article, the opinion of domain experts is weighted appreciably greater than that of non-specialists. An article’s SIQ™ will appear alongside the article after being rated twice and is recalculated with each additional ranking. CT of the abdomen sarcomatoid mesothelioma survivors exhibiting a thirteen.5 cm right decrease quadrant paracolic gutter fluid assortment. The cystic spaces have been lined by flattened endothelial-like cells or cuboidal cells with bland spherical nuclei. The reduce floor of the spleen confirmed a large mass with numerous macrocystic and microcystic spaces filled by gelatinous or haemorrhagic fluid.

A plan was made for follow-up within the clinic with surveillance imaging at 6 months and 12 months from surgery. At six months, the patient had improved abdominal signs, and CT imaging did not demonstrate any recurrence of cystic lesions in preserving national mesothelioma claims with BMPM. Physical examination revealed a delicate, non-distended stomach with tenderness to deep palpation in the left abdomen with out rebound or guarding.

Different most cancers centers have established their protocols for HIPEC. Agents used are chosen primarily based on the sort of malignancy and the experience of the surgical oncologist. The most common mixture of drugs used in this disease is cisplatin and doxorubicin . All of our sufferers obtained HIPEC following full surgical excision and they remained asymptomatic without any recurrence of BMPM. BMPM was first described in 1928 by Plaut, who incidentally observed loose pelvic cysts during an operation for uterine leiomyoma.

July 8, 2021 ​A unique case of a female patient who presented with a major acinar cell carcinoma of the liver difficult by pancreatic panniculitis. Your Member Services team is here to make certain you maximize your ACS member advantages, participate in College activities, and interact along with your ACS colleagues. Authors can add summaries to their articles on ScienceOpen to make them extra accessible to a non-specialist viewers. This link will take you to a 3rd celebration website that is not affiliated with Cureus, Inc.

Here we report a case of BMPM occurring metachronously in bilateral inguinal canals. Although the pathogenesis of BMPM continues to be unclear, reactive changes might have contributed to the development of tumors in the groin. Surgical resection is the usual treatment of selection for BMPM. Appropriate postoperative follow-up for inguinal BMPM is but to be established, and the accumulation of extra inguinal BMPM circumstances is required.

On gross examination a soft, yellowish tissue specimen was seen, measuring about 13 × 9 × 4 cm, composed of multiple cysts, as a lot as 1 cm in diameter, containing a clear fluid. It was fixed in 10% formalin, embedded in paraffin, and the sections have been evaluated by hematoxylin and eosin stain. Histologically, it consisted of cysts lined by a single layer of flattened to cuboidal mesothelial cells with out atypia. Immunohistochemistry utilizing an automatic stainer was carried out and all tumor cells showed immunoreactivity for WT1 and Calretinin.

It sometimes occurs in girls with a history of abdominal surgical procedure or other inflammatory situations inside the pelvis. BMPM is a rare scientific entity that happens most incessantly in women with a historical past of gynecologic pathology or abdominopelvic surgery. Mass impact can cause symptoms of discomfort and ache that necessitate operative administration. Further, there are reports of BMPM present process malignant transformation, but the precise danger of malignancy is unknown.

Surveillance with CT imaging is beneficial following surgical excision; nonetheless, no established tips have been determined. In basic, reviews have proven that stomach BMPM has a recurrence price of roughly 50% after surgical resection . Thus, full surgical resection seems to be an applicable choice for these patients. However, the optimum treatment for inguinal BMPM remains unclear. Owing to its rarity, the beneficial postoperative follow-up for inguinal BMPM remains to be unclear. Existing reviews have proven varying durations for follow-up, with some instances being adopted up after only a few months.

With a high frequency of misdiagnosis, patients typically face limited remedy options and a poor life expectancy, with some sufferers surviving lower than one year if tumors are composed of sarcomatoid cells. The cell structure of benign mesothelioma tumors differs based on type. Epithelioid cells are famous for rising in clusters and are a lot slower to metastasize in comparability with other cell types. Epithelial cells are also essentially the most responsive to therapy and provide a better mesothelioma prognosis.

Compared to a malignant mesothelioma tumor, a benign multicystic tumor will have many fluid-filled cysts as an alternative of multiple smaller tumors, referred to as nodules. The nomenclature for this situation could be complicated due to the usage of multiple interchangeable different synonyms that put it along with the peritoneal inclusion cysts. BMPM is more common in ladies of reproductive age, with imply age of 36 years. In feminine patients, there appears to be an affiliation between BMPM and endometriosis, pelvic inflammatory illness, and previous stomach surgical procedures. In male patients, earlier abdominal surgeries were linked to improvement of BMPM. The imply age in male patients in our case collection is sixty seven years.

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Our patient is a 46-year-old female with a previous medical historical past of endometriosis and multiple gynecological surgical procedures who offered with continuous pressure-like and burning pain within the left stomach. Due to her progression of signs, surgical management was pursued. Prior imaging studies demonstrated the presence of a hypodense, loculated fluid assortment in the left paracolic gutter that increased in size.

Our case highlights the need for further identification of BMPM threat elements, which may embody GI disease that extends to the colonic serosa (e.g., diverticulitis). While our patient is presently disease-free, there is a excessive probability that BMPM might reoccur. Therefore, additional investigation into the etiology of BMPM could elucidate novel post-surgical medical therapies for preventing disease recurrence.

Every case of benign mesothelioma manifests in a different way, and a patient’s total well being and age can have an effect on the presence or severity of signs. With a restricted number of circumstances, it’s troublesome to pinpoint widespread symptoms of benign mesothelioma, and plenty of sufferers experience no symptoms. In some cases, they could mimic signs of malignant mesothelioma, like chest ache, belly ache, weight reduction, persistent cough and pleural effusion. When cystic mesothelioma is benign, it's treatable and has a high survival rate. If removal just isn't attainable, surgical procedure might aim to reduce back the dimensions and drain fluids from the cysts. Surgical elimination can be curative; however, some sufferers have a recurrence a quantity of years later.

Recurrence is frequent, and sufferers should be adopted with serial imaging. Owing to the issue in differentiating BMPM from hernia and hydrocele of Nuck’s canal, we determined to carry out surgical procedure for obtaining a diagnosis and treating the lesion. After complete resection, the multicystic tumor was determined to have originated from the top of the hernia sac in the medial inguinal ring. The hernia was repaired using the mesh plug method, and the affected person was discharged with none issues. For multicystic peritoneal mesothelioma, research have discovered a 5-year survival fee of 90% progression-free and 10-year survival price of 72% without disease progression.

The majority of patients with BMPM are asymptomatic till the disease impacts different organs. In the 2 circumstances described right here, the primary patient’s lesion was incidentally found in the course of the patient’s hernia surgical procedure. The second patient offered with clinical symptoms and indicators suggestive of acute appendicitis however since he had prior appendectomy, other diagnoses had been sought. Imaging studies are needed to characterize the illness with CT scan being the imaging modality of selection, which often reveals a quantity of abdominal cysts. In 2014 she underwent computed tomography throughout her workup for pain and vaginal bleeding at an outdoor hospital.

A cuboidal epithelium with squamous metaplasia lined some cystic nodules crammed with eosinophilic proteinaceous materials . In all cases immunohistochemistry revealed diffuse positivity of the lining epithelium for CKPan, calretinin , HMBE-1, CK5/6, and ER with negativity for CD 34, CD31, FVIII. Over the final decade, the most common treatment has consisted of a whole resection of the tumor. However, the recurrence fee after resection is roughly 50% after a period of three to 27 months . No threat factors predicting the recurrence of MCPM have been recognized but.

A medical doctor who focuses on mesothelioma or most cancers remedy reviewed the content material on this page to ensure it meets current medical standards and accuracy. In some instances, people provoke the diagnostic process by reporting pelvic or decrease belly pain and weight reduction. After performing some standard physical exams, medical doctors typically order an imaging scan to seek out out more in regards to the underlying cause of those symptoms. This case highlights the occurrence of BMPM amongst ladies with prior pelvic inflammatory circumstances and demonstrates the chance for progress throughout the retroperitoneum. While radiographic imaging is important for evaluating this illness, diagnoses are made by pathologic evaluation of resected tissue.

Benign cystic mesothelioma of the peritoneum is a rare tumor with a high native recurrence fee. It requires optimum care in a specialized center especially as there isn't a evidence-based treatment strategies mesothelioma claims center. BMPM is a uncommon scientific entity, and surgical management is the usual treatment. Malignant transformation is uncommon but has been reported in multiple instances.

Benign Multicystic Peritoneal Mesothelioma Presenting As A Colonic Mass

We performed an entire excision of the neoformation, with free margin on omental fat. A small lesion of the colonic serosa was treated with a prophylactic steady suture with Vycril 2-0. The postoperative course was uneventful ant the affected person was discharged after 2 days without problems. Assisting mesothelioma sufferers and their family members since 2006.

The patient was a former smoker but did not have any exposure to asbestos. Our third case was a 61-year-old Caucasian male that presented with stomach ache. The affected person underwent a CT scan of the chest, abdomen, and pelvis, which revealed a ten cm cystic mass in the proper decrease stomach quadrant with no abnormality seen in chest. Patient medical history was significant for coronary artery illness, stroke, hypertension, and remote historical past of mucocele of the appendix, standing after appendectomy.

MM arises in most instances from the mesothelial lining of the pelvic peritoneum, often within the tuboovarian area. Secondary involvement of the serosa of different organs has been reported [12–14, 23]. All these totally different terms mirror the unclear origin of the illness. The current consensus is that MM just isn't sarcomatoid mesothelioma survivors a real neoplasm, however a reactive proliferation because of trauma, surgical procedure, or continual irritation . Up thus far roughly 150 circumstances have been reported all round the world.

Dr. James Stevenson is an experienced medical oncologist specializing in mesothelioma and lung most cancers treatment, currently training on the Cleveland Clinic. Survival rates range extensively depending on the subtype of mesothelioma, and if patients face a malignant recurrence. Benign mesothelioma is rarer than the malignant form, leading to a restricted variety of cases. Based on the circumstances which have accumulated, four rare subtypes have been established. While most cases are benign, some of these subtypes also can manifest as malignant cells.

Benign multicystic peritoneal mesothelioma is generally thought of a peritoneal reaction secondary to continual irritation with mesothelial cell entrapment, reactive proliferation, and cystic formation . Studies have shown that 30–87% of sufferers who developed BMPM had beforehand undergone belly surgery . Moreover, persistent inflammation, endometriosis, and peritonitis related to peritoneal dialysis have also been reported to be involved in the growth of BMPM . In addition, some reports have discovered that cystic tumors are fashioned when ovarian fluid is trapped in peritoneal adhesions or irritation . However, different reports consider BMPM to be an oncological prevalence.

We would like to report here the primary case of MM originating in the spleen of the female affected person with a previous diagnosis of endometriosis of the best ovary treated with splenectomy. Life expectancy is usually unaffected by a benign mesothelioma diagnosis, and most sufferers are able to stay a full life after the tumor is eliminated. However, recurrence is possible, especially for benign multicystic peritoneal mesothelioma. Tumors can return as malignant, which would then present patients with a very poor prognosis depending on the stage of cancer and site. On common, malignant mesothelioma patients survive 12 to 21 months.

Moreover, pathological findings showed characteristics much like the earlier, with epithelial cells being optimistic for calretinin and D2-40 following immunostaining. After surgery, the patient was discharged with no complications, and no tumor recurrence was found for 33 months. Here we current the first report of metachronous BMPM occurring in bilateral inguinal canals. Although the pathogenesis of BMPM remains mesothelioma cancer treatment unclear, reactive changes have been suggested to cause tumors originating from the groin. For diagnosis, pathological examination with immunostaining could be helpful. The most applicable postoperative follow-up for inguinal BMPM is controversial, and the accumulation of more inguinal BMPM circumstances is required.

Please note that NORD supplies this info for the benefit of the uncommon illness neighborhood. NORD isn't a medical provider or health care facility and thus can neither diagnose any illness or dysfunction nor endorse or advocate any specific medical remedies. Repeat imaging in January 2020 showed a similar mass, along with numerous scattered mesenteric and peritoneal nodules inside the stomach and pelvis regarding a peritoneal neoplasm . Follow-up CT in August 2019 was significant for extreme colonic diverticulosis and a proper paracolic gutter lobular fluid-attenuated structure with options of a cystic lymphangioma that measured 11.7 cm . The affected person opted for continued observation and repeat imaging. Multicystic mass positioned in the pelvis with a decreased sign on T1-weighted picture however an increased signal intensity on T2-weighted picture .

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In most cases, the tumor originates in the pelvic region of the peritoneum. In some cases, it originated within the peritoneum near the bladder, uterus, rectum, or in the omentum, a layer of fats that covers the stomach cavity. She is a registered nurse with a background in oncology and thoracic surgical procedure and was the regional director of a tissue bank earlier than changing into a Patient Advocate at The Mesothelioma Center. Karen has assisted surgeons with thoracic surgical procedures corresponding to lung resections, lung transplants, pneumonectomies, pleurectomies and wedge resections. She can also be a member of the Academy of Oncology Nurse & Patient Navigators. According to a 2018 case report revealed in Case Reports in Surgery, the vast majority of sufferers do not expertise signs till the tumor is large sufficient to have an impact on other organs.

Multiple therapy strategies have been tried to deal with BMPM. Yet, complete cytoreduction adopted by instillation of hyperthermic intraperitoneal chemotherapy remains the therapy of choice. This modality is assumed to decrease the recurrence price and allow removing of microscopic residual tumor.

Malignant mesothelioma usually forms calcified plaques or nodules as a substitute of the liquid-filled cysts that develop from cystic mesothelioma. The cells in malignant mesothelioma tumors additionally show elevated exercise, which doctors can detect with a way called immunohistochemical staining. Benign cystic mesothelioma of the peritoneum is a rare, benign belly tumor. It can present with obscure signs and signs and is often discovered on imaging or incidentally during surgery.

Therefore, a radical analysis of the whole omentum for extra plenty and nodules must be performed in all patients with BMPM. While there aren't any established surveillance guidelines, a suggestion of repeat CT every three months for a year, adopted by annual CT scans for the subsequent 5 years has been published . A 48-year-old feminine was referred to our hospital for a bulge in her left inguinal area. A subsequent medical examination revealed a golf ball-sized nodule in the left inguinal region that could not be pushed again into the abdominal cavity. Contrast-enhanced computed tomography revealed a multicystic tumor in the same area and the tumor was 38 mm in diameter. Bilateral normal ovaries have been found within the pelvis with no ascites (Fig.1A).

We want to thank Dr. Tsutomu Sakuma from the Department of Pathology and Diagnostics for the pathological analysis of the present case. We want to thank Enago () for English language editing. However, a definitive analysis requires histology as nicely, and the intraoperative examination is pointless because the prognosis requires immunohistochemistry. The info supplied mesothelioma settlement after death by Mesothelioma.internet just isn't an alternative choice to skilled medical advice, prognosis or treatment. She completed her 5-years of postdoctoral coaching within the Department of Experimental Therapeutics at MD Anderson Cancer Center. She is at present working in the field of most cancers as a analysis scientist.

Multicystic and well-differentiated papillary peritoneal mesothelioma handled by surgical cytoreduction and hyperthermic intra-peritoneal chemotherapy . A 74-year-old male with a past medical historical past of diverticulitis introduced to the clinic in November 2018 for analysis of a recurrent 13.5 cm proper decrease quadrant paracolic gutter fluid collection . Routine colonoscopy in July 2018 was significant for small-mouthed diverticula in the sigmoid colon and non-bleeding internal hemorrhoids. Thereafter, the intraabdominal fluid collection re-accumulated and subsequent CT-guided IR drainage confirmed no evidence of malignancy.

Please notice that Cureus just isn't answerable for any content or activities contained inside our partner or affiliate websites. The proper lower quadrant mass measured roughly thirteen cm and the left higher quadrant mass measured approximately 5 cm. CT of the abdomen displaying numerous scattered mesenteric and peritoneal nodules. Your browser will redirect to your requested content shortly. The authors declare that they do not have any monetary or potential conflicts of interest of any type.

In one case research, a thirty-six-year-old girl was recognized with benign cystic peritoneal mesothelioma. She underwent six separate surgeries to reduce the mass of the large tumor. As her doctors tracked the progression of the tumor, they found it had remodeled into most cancers, invading tissue, together with the lymph nodes. A physician then performs a biopsy to withdraw fluid and cells from the tumor.

Benign multicystic peritoneal mesothelioma is a uncommon neoplasm of the stomach mesothelium (i.e., peritoneum, mesentery, and omentum). We current the case of a 74-year-old male who presented with a right paracolic gutter fluid assortment and cystic mass. The patient underwent diagnostic laparoscopy with resection of the mass. The pathogenesis may have been related to longstanding diverticular illness, which could prove to be an underrecognized danger factor for the event of BMPM. Therefore, this case suggests a broadened differential diagnosis to incorporate BMPM in particular cases of pre-operatively recognized colonic plenty. Multicystic mesothelioma is a comparatively uncommon tumour arising within the pelvic peritoneum of the tuboovarian region of younger woman.

A pink-tan, easy, intact, thin-walled cystic mass was removed. The mass weighed 136 grams, measured 9.5 cm × 8.1 cm × 4.zero cm, and had a number of attached daughter cysts (0.2 cm‒0.7 cm). All cysts contained a thin, clear fluid with no strong areas recognized. The histologic examination was in maintaining with BMPM, displaying cysts lined with mesothelial cells and foci of fibroblastic/mesothelial proliferation together with numerous blood vessels within the stroma .

Primarily occurs within the pelvic peritoneum, but can be multicompartmental 2. Click right here for info on linking to our web site or utilizing our content material or images. Rare paediatric case of agenesis of the vermiform appendix, ileal duplication and sickle cell disease. Contrast enhanced axial picture that show the presence of a polylobate hypodense formation, with multiple thin inner septa. All authors have contributed significantly, and all authors approve the content material of the manuscript. Mesothelioma Center - Vital Services for Cancer Patients & Families doesn’t believe in promoting buyer information.

EBH and AB participated in writing the case report and revising the draft, OM, EB, AO, KM and KAT participated in the comply with up.

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